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Prescribing should be consistent with the need to minimize TD. If antipsychotic treatment is withdrawn, TD may remit, partially or completely. TD can develop after a relatively brief treatment period, even at low doses, or after discontinuation. Tardive Dyskinesia (TD): Risk of TD, and the potential to become irreversible, are believed to increase with duration of treatment and in total cumulative dose of antipsychotic drugs.
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Manage NMS with immediate discontinuation of ABILIFY MYCITE, intensive symptomatic treatment, and monitoring. Additional signs may include elevated creatine phosphokinase, myoglobinuria (rhabdomyolysis), and acute renal failure. Clinical signs of NMS are hyperpyrexia, muscle rigidity, altered mental status, and evidence of autonomic instability. Neuroleptic Malignant Syndrome (NMS): NMS is a potentially fatal symptom complex reported in association with administration of antipsychotic drugs, including ABILIFY MYCITE. Reactions have ranged from pruritus/urticaria to anaphylaxis.Ĭerebrovascular Adverse Events, Including Stroke, in Elderly Patients with Dementia-Related Psychosis: Increased incidence of cerebrovascular adverse events (e.g., stroke, transient ischemic attack), including fatalities, have been reported in clinical trials of elderly patients with dementia-related psychosis treated with aripiprazole. The safety and effectiveness of ABILIFY MYCITE have not been established in pediatric patients.Ĭontraindication: Known hypersensitivity reaction to aripiprazole.
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Advise families and caregivers of the need for close observation and communication with the prescriber. Those on antidepressant therapy should be monitored closely for worsening, and for emergence of suicidal thoughts and behaviors. WARNING: SUICIDAL THOUGHTS AND BEHAVIORSĪntidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults. ABILIFY MYCITE is not approved for the treatment of patients with dementia-related psychosis. IMPORTANT SAFETY INFORMATION WARNING: INCREASED MORTALITY IN ELDERLY PATIENTS WITH DEMENTIA-RELATED PSYCHOSISĮlderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death (1.6 to 1.7 times) compared to placebo-treated patients.